WAY 600
WAY-600
CAS: 1062159-35-6
Molecular Formula: C28H30N8O
WAY 600 - Names and Identifiers
WAY 600 - Physico-chemical Properties
| Molecular Formula | C28H30N8O |
| Molar Mass | 494.59 |
| Density | 1.43 |
| pKa | 16.08±0.30(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | WAY-600 exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically decreased. Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. WAY-600 dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM). |
| In vivo study | Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, p.o. daily). |
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Product Name: 4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine Request for quotationCAS: 1062159-35-6
Tel: 400-968-2212
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Mobile: 18916960931
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Product Name: WAY-600 Visit Supplier Webpage Request for quotationCAS: 1062159-35-6
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Product Name: WAY-600 Visit Supplier Webpage Request for quotationCAS: 1062159-35-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
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Mobile: 609-228-6898
Product Name: WAY-600 Visit Supplier Webpage Request for quotation
CAS: 1062159-35-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1062159-35-6
Tel: 18301782025
Email: 3008007409@qq.com
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